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- _3 value "These results were confirmed by immunoblot analysis of phosphorylated S6 and 4E-binding protein 1 in hepatic lysates (Fig. 3C). Phosphorylation of S6 was inhibited by either regimen of rapamycin administration 4 h after the last dose on day 5, but recovery was different. S6 phosphorylation recovered less with the qod schedule. Interestingly, phosphorylation of 4E-binding protein 1 did not recover during the washout period with either regimen. The basis for these differences in the recovery of phosphorylation of S6 and 4E-binding protein 1 is unclear, but it suggests that S6 phosphorylation might more accurately reflect rapamycin levels than phosphorylation of 4E-binding protein 1" provenance.
- _3 wasQuotedFrom 17404113 provenance.