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- _3 value "oxidative stress contributes to the protease/anti-protease imbalance by inactivating ?-1 anti-trypsin (MacNee & Rahman 2001). Oxidants also promote inflammation, for example by activating the redox-sensitive transcription factor NF-?B, which orchestrates the expression of multiple inflammatory genes important in the pathogenesis of COPD, such as interleukin-8 (IL-8) and tumor necrosis factor-? (TNF-?)" provenance.
- _3 wasQuotedFrom 16324149 provenance.