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- _5 value "In many cells, FAK activation leads to the Src homology 2 (SH2) domain-mediated binding to Src-family protein tyrosine kinases (PTKs) to the motif surrounding the FAK Tyr-397 phosphorylation site.It is this dual FAK-Src complex that promotes the tyrosine phosphorylation of substrates such as paxillin and p130Cas and FAK-Src-associated signaling can lead to the activation of multiple protein kinase cascades [2-4]." provenance.
- _5 wasQuotedFrom 15108811 provenance.