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- _5 value ". A major mechanism of cell necrosis is the opening of the mitochondrial permeability transition pore (mPTP), which consists of multiple protein subunits, including adenine nucleotide translocase (ANT). The threshold for mPTP opening is elevated by phosphorylation of GSK-3beta at Ser9, which reduces activity of this kinase. {FROM FULL TEST: The mPTP is a non-selective large conductance channel in the mitochondrial inner membrane, which is physiologically closed. Opening of mPTPs is involved in cell death induced by a variety of causes (for example, ischemia/reperfusion, alcohol, endotoxin, anti-cancer agents), therefore 'opening' is modeled as tportof(mitochondrial permeability transition pore) and increased threshold for opening is modeled as decrease in tportof -SE}" provenance.
- _5 wasQuotedFrom 19506320 provenance.