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- _4 value "No pretreatment or pretreatment with insulin for 4 hours resulted in similar levels of Bovine growth hormone induced tyrosine phosphorylated STAT5. However following insulin pretreatment for 16, 20, 24 hours, bGH- induced phosphorylated Stat5 was reduced. Moreover Insulin pretreatment for 16 hours also significantly inhibited bGH induced Jak2 tyrosine phosphorylation. These results demonstrate that Growth hormone stimulated Jak2/Stat5 phosphorylation was inhibited by chronic insulin treatment and Jak2 mediates STA5B phosphorylation." provenance.
- _4 wasQuotedFrom 10224108 provenance.