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- _4 value "Several recognition sites are present on the promoter of the cytochrome c gene, including the cAMP response element binding-protein (CREB) and nuclear respiratory factor 1 (NRF-1). Both these transcription factors are activated by phosphorylation of serine residues (Figs. 1b, 2). In BALB/3T3 cells, cAMP leads to activation of PKA, which, in turn, activates the transcription factor CREB and up-regulates the cytochrome c gene [29]." provenance.
- _4 wasQuotedFrom 16568236 provenance.