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- _5 value "Protein kinase C (PKC) is a serine kinase that has a number of potential substrates, including the insulin receptor (152). PKC is activated by the intracellular metabolite diacylglycerol (DAG), the concentration of which increases in a glucose-dependent manner during exposure of isolated muscles to hyperinsulinemia (153). In NIH3T3 cells overexpressing the insulin receptor, insulin desensitization by glucose can be blocked by PKC inhibitors and thiazolidinediones (154)." provenance.
- _5 wasQuotedFrom 10194465 provenance.