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- _8 value "To identify potential physiological inducers of IKKepsilon, a dominant-negative version of each of the three IkB kinases was cotransfected with an NF-kB reporter gene into HeLa cells, which were then treated with TNFalpha or IL-1 (Figure 4A). Consistent with previous work ( [30, 37 and 46]), the dominant-negative IKKalpha (dnIKKalpha) slightly inhibited the activation of the NF-kB reporter gene by TNFalpha and IL-1, while the dnIKKbeta virtually abolished NF-kB activation by both inducers." provenance.
- _8 wasQuotedFrom 10882136 provenance.