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- _6 value "We next examined whether mutations of this MEF2 site affects MEF2 activity on the PGC-1? promoter. The mutated 2-kb promoter (called ?MEF2; see Fig. 3A) is no longer able to mediate MEF2C or MEF2D induction alone, when activated by CnA or coactivated by PGC-1?, suggesting that this site is responsible for the MEF2 action (Fig. 3B). Moreover, electrophoretic mobility-shift assays revealed binding of MEF2C to this MEF-binding site but not the mutated ?MEF site in the PGC-1? promoter (Fig. 3C). The identity of the MEF2C?DNA complex was confirmed by using an anti-MEF2 antibody that leads to a supershift of the DNA?protein complex." provenance.
- _6 wasQuotedFrom 12764228 provenance.