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- _3 value "Mat2a promoter is hypomethylated in hepatocellular carcinoma, in which the gene is upregulated transcriptionally, but hypermethylated in normal liver, in which the gene is minimally expressed treatment of adult rat and human hepatocytes with trichostatin A, an inhibitor or histone deacetylase, upregulated Mat2a expression by more than fourfold these results suggest that Mat2a expression is regulated by promoter methylation and histone acetylation" provenance.
- _3 wasQuotedFrom 11208539 provenance.