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- _5 value "Interestingly, when lysates from co-transfection experiments were blotted with anti-receptor antibodies, a loss of EGFR, ErbB2, ErbB3, and ErbB4 was observed in the presence of LRIG1, but no loss of insulin receptor was observed despite very efficient transfection of these cells (Fig. 1C, compare lanes 1 and 3 in all panels). These observations suggest that a functional consequence of LRIG1 interaction with receptor tyrosine kinases may be suppression of receptor levels to lower the efficiency of signaling." provenance.
- _5 wasQuotedFrom 15345710 provenance.