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- _4 value "Treatment of U937 cells with TNF-alpha for 5 min increased the intracellular concentration of ceramide, however it was prevented by incubation with D609 (which inhibits acidic Sphingomyelinase activity). Further showed that D609 also inhibited the TNF-alpha induced apoptosis. This suggests that TNF-alpha induced ceramide generation and apoptosis were mediated by sphingomyelinase." provenance.
- _4 wasQuotedFrom 10792026 provenance.