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- _5 value "Interestingly, ectopic Par-4 overexpression is sufficient to induce apoptosis in most cancer cells, but not in normal or immortalized cells, and this action of Par-4 does not require the leucine zipper domain Apoptosis by ectopic Par-4 involves activation of the Fas death receptor signaling pathway and concurrent nuclear factor-nB (NF-nB) inhibition, which withdraws the antiapoptotic roadblocks and allows the caspase cascade to proceed uninterrupted" provenance.
- _5 wasQuotedFrom 16540633 provenance.