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- _5 value "The ability of Tpl2 to regulate COX-2 expression depends on ERK signals that activate p90Rsk and Msk1, which in turn phosphorylate CREB, a key regulator of COX-2 transcription. The ERK phosphorylates p90Rsk at serine-364, 381 and threonine-360, which in turn phosphorylates Creb1 at serine-133 in cells treated by the LPS. The ERK mediated phosphorylation of p90Rsk was abrogated in Tpl2-/- cells. {Tpl2 Official Gene Symbol: MAP3K8, p90Rsk Official Gene Symbol: Rps6ka1, Msk1 Official Gene Symbol: Rps6ka5}" provenance.
- _5 wasQuotedFrom 12234923 provenance.