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- _6 value "c-Abl is an upstream regulator of the profibrotic PKCdelta/phospho-Fli-1 pathway, via induction of PKCdelta nuclear localization. Additionally, the finding that Fli-1 is phosphorylated (Thr312 phosphorylation) at higher levels in SSc fibroblasts supports the notion that the c-Abl/PKCdelta/phospho-Fli-1 pathway is constitutively activated in these cells. Thus, blocking the TGFbeta/c-Abl/PKCdelta/phospho-Fli-1 pathway could be an attractive alternative approach to therapy for scleroderma." provenance.
- _6 wasQuotedFrom 21321929 provenance.