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Oxidation of arachidonic acid to 5-HpETE. 5-lipoxygenase (5-LO) catalyzes the formation of leukotriene A4 (LTA4) from arachidonic acid (AA) in a two-step process. First, AA is oxidized to form 5-hydroperoxyeicosatetranoic acid (5-HpETE).
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