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- _6 value "Hydroxylation at two prolyl residues (Pro402 and Pro564 in human HIF-1?) mediates interactions with the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex that targets HIF-? for proteasomal destruction28, 29, 30, 34. Each site can interact independently with VHL E3, potentially contributing to the extremely rapid proteolysis of HIF-? that is observed in oxygenated cells34. These sites contain a conserved LxxLAP motif and are targeted by a newly defined prolyl hydroxylase activity, that in mammalian cells is provided by three isoforms termed PHD (prolyl hydroxylase domain) 1-3 (refs. 31,32)." provenance.
- _6 wasQuotedFrom 12778166 provenance.