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- _5 value "In these experiments p53â??223Leu was as active as wild-type p53 in transactivation of the reporter construct, whereas p53â??274Phe had no detectable activity (Fig. 4b). Coexpression of p53â??274Phe inhibited transactivation by p53â??223Leu, thus correlating with the above-described effects of this mutant on growth-inhibitory activity of p53â??223Leu. The lack of detectable transactivation activity of p53â??274Phe suggests that the toxicity of this protein to 10(1) cells is mediated not through p21." provenance.
- _5 wasQuotedFrom 12782597 provenance.