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- _4 value "Fetal brown adipocytes primary cultures offer an excellent cell model to study the molecular mechanisms of insulin/IGF-I-mediated differentiation processes. In these cells insulin and IGF-I, acting independently, up-regulate the expression of adipogenic-related genes (fatty acid synthase, glycerol-3-phosphate dehydrogenase, malic enzyme, glucose- 6-phosphate dehydrogenase) in a dose and time-dependent manner at the transcriptional level, resulting in an increase of cytosolic lipid content [20,40]." provenance.
- _4 wasQuotedFrom 15777261 provenance.