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- _3 value "SIRE (Sterol-independent regulatory element, -17 to -1) is the LDLR promoter region which overlaps the TATA-like element and consists of a C/EBP binding site and a functional cAMP responsive element (CRE). Three DNA-protein complexes (C1, C3 and C4) were detected in control extracts and 4 complexes (C1, C2, C3 and C4) were detected in oncostatin M-treated nuclear extracts using a P32-labeled oligonucleotide probe (TATA1+2) containing LDLR promoter sequence -25 to +5. EMSA studies demonstrated that the C3 complex in both control and OM-treated extracts was completely supershifted by anti-CREB1 antibodies. The results suggest that the transcription factor cAMP-responsive element binding protein (CREB-1) binds to the SIRE region of LDLR and C3 is composed of homodimers or heterodimers of the CREB family." provenance.
- _3 wasQuotedFrom 10671569 provenance.