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- _4 value "To obtain direct evidence of TLR activation upon THP engagement, we isolated bone marrow?derived macrophages from MyD88 and TLR2, TLR4, and TLR9 KO mice as well as from WT mice. While THP potently stimulated TNF-? production in APCs obtained from WT, TLR2?/?, and TLR9?/? mice, cells from TLR4?/? and MyD88?/? mice were completely resistant to THP or LPS stimulation (Figure ?(Figure6A).6A)" provenance.
- _4 wasQuotedFrom 15650774 provenance.