Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAcpyWKASWbeV-g0LgBXFWODmYOtOa_ndNR65bBoJ8Lug#_4> ?p ?o ?g. }
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- _4 value "{Modeled as TP63 and not taof because the 'dominant negative' TP63 lacking a transcriptional activation domain also activates the gene - SE} We determined that the trans-activator (TA) isoforms of p63 activate MFGE8 transcription though a p53/p63 motif at -370, which was confirmed by a chromatin immunoprecipitation experiment. Upon siRNA-mediated p63 silencing in a squamous cell carcinoma line, MFG-E8 production decreased to diminish Saos-2 cell adhesion. Interestingly, the DeltaN-p63 isoform lacking the TA domain enhanced the MFGE8-activating function of TA-p63" provenance.
- _4 wasQuotedFrom 17637751 provenance.