Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAcq4X8GLKn5Svln6wvzeQNb7nP3Wq-ubUt7R8V43hwYA#_3> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _3 value "Expression of CCN1 protein was detected in normal ovarian epithelial cells and ovarian tumors as well as in ovarian cancer cell lines. Furthermore, estrogen increased CCN1 mRNA and protein levels in ovarian cancer cells. Ectopic expression of CCN1 enhanced the growth of ovarian cancer cells in liquid culture, whereas inhibition of its expression decreased proliferation and increased apoptosis in these cells. The observed changes in cell growth were accompanied with activation of Akt and extracellular signal-regulated kinase (ERK) signaling pathways. Stable expression of CCN1 in SKOV3 cells significantly increased tumorigenicity in nude mice." provenance.
- _3 wasQuotedFrom 16243794 provenance.