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- _7 value "in a substantial proportion of patients with primary breast cancer, and in all patients with ER positive metastatic disease, resistance eventually develops to all strategies that are designed to limit ER activation by oestrogen. ER binds as a dimer to small palindromic DNA motifs - known as oestrogen response elements (EREs) - in the promoters of these genes, through the action of two ZINC FINGERS 29. AF1 and AF2 activate transcription independently and/or synergistically. There is evidence that AF1 and AF2 activities are influenced by the promoter and cell type 32. Three related co-activators, collectively known as the p160 co-activators, stimulate ER activity following ligand stimulation, through direct interaction with AF2 (reviewed in REFS 45,46)." provenance.
- _7 wasQuotedFrom 12635173 provenance.