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- _4 value "FROM TEXT and Figure 6: Hybridization to the U133A DNA microarray,Genes downregulated in NANOG overexpressing cells and 2- day-old EBs compared with wild-type ES cells (Fig. 6D). These may be ICM (and therefore ES cell) markers that are downregulated upon the transition to primitive ectoderm. Among these genes are LECTIN (LGALS1), a known marker of HESCs (Dvash et al., 2004) that is absent from all samples but ES cells, and HOXA1 (homeo box A1), a transcription factor involved in development. Among the genes downregulated in NANOG overexpressing cells but to a smaller extent are genes suggested to be downstream targets of HOXA1 (Shen et al., 2000), such as GBX2 and BMP2." provenance.
- _4 wasQuotedFrom 16501172 provenance.