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- _5 value "Finally, we show that retroviral T-bet expression in developing and established Th2 cells leads to down-regulation of GATA-3 levels. (from text): As shown in Fig. 5 E, although GATA-3 mRNA levels in untreated T-bet?expressing D10 cells were suppressed to about half of the level found in the wild-type cells, the kinetics of degradation of GATA-3 mRNA was similar in T-bet?expressing and nonexpressing D10 cells. These results suggest that T-bet suppresses GATA-3 at a transcriptional level rather than at a posttranscriptional level. However, it should be noted that some posttranslational control may also exist because the down-regulation of GATA-3 by T-bet is more evident at the protein level than it is at the mRNA level." provenance.
- _5 wasQuotedFrom 16520391 provenance.