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- _6 value "The FAK and Shc pathways are regulated both positively and negatively by tyrosine phosphatases. Integrin-mediated activation of ERK is suppressed in cells that lack the re- ceptor-type protein tyrosine phosphatase a or the cytosolic phosphatase SHP-2 (19). These enzymes dephosphorylate the negative regulatory site in Src-family kinases and thus, presumably, amplify both FAK and Shc signaling." provenance.
- _6 wasQuotedFrom 10446041 provenance.