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- _6 value "Real-time PCR primers were designed for the PGC-1? 3' untranslated region that allows for determination of the levels of ectopically expressed and endogenous PGC-1?. As shown in Fig. 4B and as expected, ectopic PGC-1? is detected only in the muscle of transgenic mice. Strikingly, a 7-fold elevation of endogenous PGC-1? mRNA was seen in the transgenic animals as compared with wild-type mice (Fig. 4B). A robust increase in the transcript levels of cytochrome c and myoglobin also was observed in the RNA isolated from skeletal muscle of the transgenic mice, whereas GAPDH transcript levels remained unchanged (Fig. 4B). These results indicate a regulation of PGC-1? transcription by PGC-1? protein in an apparent autoregulatory loop." provenance.
- _6 wasQuotedFrom 12764228 provenance.