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- _4 value "Thrombopoetin (TPO) induced the phosphorylation of Jak2 in BaF3/mMpl cells. Pretreatment of BaF3/mMpl cells and mature megakaryocytes (MKs) with IFN-alpha for 4 hours before stimulation with TPO, inhibited the TPO-induced Jak2 phosphorylation. It is observed that Jak2 phosphorylation was blunted by IFN-alpha and is most consistent with the action of Socs-1 which appears responsible for impaired TPO signaling. Phosphorylation of Jak2 was reduced in the presence of TPO plus IFN-alpha to 45% than that seen in cells cultured in TPO alone. In primary murine MK cultured in TPO plus IFN-alpha, Jak2 phosphorylation was reduced to 75%, compared to cultures containing TPO alone." provenance.
- _4 wasQuotedFrom 10979953 provenance.