Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ#_4> ?p ?o ?g. }
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- _4 value "IGF-I, but not vitamin D3, caused a sevenfold increase in the enzymatic activity of both PI 3-kinase and atypical PKC-zeta. Inhibition of IGF-I-inducible PI 3-kinase with either wortmannin or LY294002 abrogated the IGF-I-induced activation of PKC-zeta and totally blocked the enhancement in macrophage differentiation caused by IGF-I. These data establish that PKC-zeta is a putative downstream target of PI 3-kinase that is activated during IGF-I-promoted macrophage differentiation." provenance.
- _4 wasQuotedFrom 9570559 provenance.