Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAdycZRJK6cURkIMbF349HeVjClcuJqNAViYZpYaabKkA#_5> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _5 value "A8 is only expressed in elicited Mac following activation. LPS- (17), IFN-, and TNF-induced gene expression is modulated by Ca2+ and by pathways involving protein kinase (PK)C, leading to activation of mitogen-activated (MA)PK (18). IL-10, but not IL-4 or IL-13, down-regulates MHC class II expression and Ag presentation by monocytes (23) and up-regulates monocyte chemoattractant protein (MCP)-1 production by blood monocytes and alveolar Mac (24, 25), IL-10 strongly synergized with LPS or IFN to markedly enhance A8 secretion. Synergy may involve a cAMP-dependent pathway, acting principally at the level of transcription, and was confined to a small region of the proximal promoter containing binding sites for Ets and CCAAT/enhancer binding protein (C/EBP) transcription factors." provenance.
- _5 wasQuotedFrom 11342660 provenance.