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- _6 value "Since insulin activates eNOS through Akt, we then investigated whether FFAs have any effects on basal and insulin-stimulated Akt activation, which was monitored by phosphorylation at Ser473 and Ser308 sites. We observed that while linoleic acid had no effects on Akt phosphorylation at Ser473, palmitic acid inhibited Akt phosphorylation at both Ser473 and Ser308 sites in a dose-dependent fashion (Fig. 2A). Palmitic acid also inhibited insulin-stimulated Akt phosphorylation at Ser473 (Fig. 2B), suggesting that palmitic acid may block upstream signaling. " provenance.
- _6 wasQuotedFrom 16873694 provenance.