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- _3 value "However, IL-1?-induced NF-?B activity is attenuated by increased intracellular calcium in response to ionomycin, UTP, or thapsigargin or by overexpression of CaMKKc and/or Akt. Ionomycin and CaMKKc overexpression increases Akt phosphorylation on Thr308 and enzyme activity. Under these conditions or upon overexpression of wild type Akt, IL-1?-induced IKK? activity is diminished. Furthermore, a dominant negative mutant of Akt abolishes IKK? inhibition by CaMKKc and ionomycin, suggesting that Akt acts as a mediator of CaMKK signaling to inhibit IL-1?-induced IKK activity at an upstream target site." provenance.
- _3 wasQuotedFrom 11976320 provenance.