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- _7 value "Grb2 constitutively associates with Sos, the guanine nucleotide exchange factor for plasma membrane-bound Ras (36). Docking of Grb2 to IRS proteins recruits Sos to Ras, resulting in activation of its GTPase Following insulin stimulation, Grb2 binds to both IRS proteins and to Shc, and it is not clear which pathway is more important for its activity (37, 38)" provenance.
- _7 wasQuotedFrom 10194465 provenance.