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- _5 value "In SP-C/Dkk1 embryos, however, BMP4 expression is significantly reduced (Fig. 5J). As discussed above, at E12.5, the efficiency of ?-catenin excision in many SP-C/rtTA:tetO-cre X ?-cateninflox embryos is less than 100% in some embryos resulting in a mosaic pattern of ?-catenin expression in the lung airway epithelium. However, this result proves advantageous since we can determine in a precise cell specific manner whether loss of ?-catenin leads to a loss of BMP4. As expected, BMP4 and ?-catenin are expressed at high levels in distal airway epithelium in wild-type lungs at E12.5 (Figs. 5K? M). Lungs exhibiting mosaic expression of ?-catenin also express BMP4 in a mosaic pattern that closely correlates with presence of ?-catenin (Figs. 5N?P). Complete loss of ?-catenin leads to a complete loss of BMP4 expression (Figs. 5Q?S)." provenance.
- _5 wasQuotedFrom 15907834 provenance.