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- _5 value "Further, Myc-induced transcription was shown to be Skp2 dependent, suggestinginterdependence between c-Myc and Skp2 in activation of transcription. Moreover,Myc-dependent association of Skp2, ubiquitylated proteins, and subunits of theproteasome to a c-Myc target promoter was demonstrated in vivo. The resultssuggest that Skp2 is a transcriptional cofactor for c-Myc and indicates a closerelationship between transcription activation and transcription factorubiquitination." provenance.
- _5 wasQuotedFrom 12769844 provenance.