Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAfGoPgkRWelbZk0qERv-GnTAYeeHHW52cFl-1-eDP-2c#_6> ?p ?o ?g. }
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- _6 value "Mechanisms of Akt3 deregulation occurred through a combination of overexpression of Akt3 accompanying copy number increases of the gene and decreased PTEN protein function occurring through loss or haploinsufficiency of the PTEN gene. Targeted reduction of Akt3 activity with siRNA or by expressing active PTEN protein stimulated apoptotic signaling, which reduced cell survival by increasing apoptosis rates thereby inhibiting melanoma tumor development" provenance.
- _6 wasQuotedFrom 15466193 provenance.