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- _5 value "To identify a function that could be linked specifically to Akt-Ser473 phosphorylation, we further examined known Akt substrates that may have defective phosphorylation in SIN1?/? cells. We found that phosphorylation of FoxO1/3a (also called FKHR/FKHRL1) (Greer and Brunet, 2005), was affected in SIN1?/? cells. In particular, phosphorylation of FoxO1/3a at Thr24/Thr32 was significantly decreased in the absence of SIN1 under normal growing and restimulated conditions (Figure 4A)." provenance.
- _5 wasQuotedFrom 16962653 provenance.