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- _5 value "HNF-3beta was also necessary for expression of HNF-3alpha. In contrast, HNF- 3alpha acts as a negative regulator of HNF-4alpha/HNF-1alpha demonstrating that HNF-3alpha and HNF-3beta have antagonistic transcriptional regulatory functions in vivo.HNF-3alpha does not appear to act as a classic biochemical repressor but rather exerts its negative effect by competing for HNF-3 binding sites with the more efficient activator HNF-3beta." provenance.
- _5 wasQuotedFrom 9685261 provenance.