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- _4 value "ecause cross talk between numerous mechanisms of proinflammatory cytokine activation after cigarette smoke exposure likely occurs, we investigated the role of Egr-1 in the absence of CSE. After transfection of Egr-1 (pCMV?Egr-1), secreted IL-1beta was significantly elevated (Figure 7A). Significant increases in IL-1beta secretion were observed in A-549 cells transfected with 200 and 400 ng of Egr-1 " provenance.
- _4 wasQuotedFrom 16601242 provenance.