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{ <http://www.tkuhn.ch/bel2nanopub/RAfgSciADNLYozGY1bd3ekMLyj-ejRqrjgO8uQ_lVWdE4#_6> ?p ?o ?g. }
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The IGF-1 receptor (IGF-1R) and MT1-MMP are synthesized as larger precursor proproteins, which require endoproteolytic activation by the proprotein convertases (PCs) furin/PC5 to gain full biological activity.
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