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- _3 value "from full text - It has been reported that cytokine IL-12 may act in synergy with IL-18 to promote the induction of IFN-gamma, leading to severe gut inflammation in mice[39]. The development of Th1 CD4+ T cells in the intestinal mucosa is driven by IL-12, produced from activated macrophages, and IL-18, produced from activated macrophages and colonic epithelial cells. The synergistic effect is mainly caused by mechanisms involving the upregulation of the IL-18 receptor by IL-12[40]." provenance.
- _3 wasQuotedFrom 18666314 provenance.