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- _7 value "However, FGFR-1-mediated MAPK activation was not dependent on PKC activation or intracellular calcium, both downstream mediators of PLC-gamma activation. We report that the adaptor protein Shb is also able to bind tyrosine 766 in the FGFR-1, via its SH2 domain, resulting in its subsequent phosphorylation. Overexpression of an SH2 domain mutant Shb caused a dramatic reduction in FGFR-1-mediated FRS2 phosphorylation with concomitant perturbment of the Ras/MEK/MAPK pathway. -- ( [bcd] FFT Figure 9. Shb regulates FGFR-1-mediated FRS2 phosphorylation. Samples were resolved by SDS-PAGE (10% polyacrylamide), transferred electrophoretically, and blotted with an antiphosphotyrosine antibody (4G10). )" provenance.
- _7 wasQuotedFrom 12181353 provenance.