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- _3 value "This action releases activated NF-kB, which is then translocated to the nucleus where it mediates transcription of antiapoptotic factors.155,166 Other antiapoptotic effects of C-Raf are mediated by a mitochondrial pool of the protein, which, on stimulation, localizes to the mitochondrial membrane where the protein interacts with and phosphorylates Bcl-2, Bcl-2-associated athanogene, and other pro-apoptotic regulators, abrogating their pro-apoptotic effects." provenance.
- _3 wasQuotedFrom 16170185 provenance.