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- _5 value "IKKb can impact on insulin signaling through at least 2 pathways. First, it can directly phosphorylate IRS-1 on serine residues (34, 57). Second, it can phosphorylate inhibitor of NF-kB (IkB), thus activating NF-kB, a transcription factor that, among other targets, stimulates production of multiple inflammatory mediators, including TNFalpha and IL-6 (58)." provenance.
- _5 wasQuotedFrom 15864338 provenance.