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- _4 value "SCD and D6D/D5D, these desaturases share common regulatory freatures, including dependence of expression on insulin, suppression by highly unsaturated fatty acids, and induction by peroxisome proliferators. A key regulator of desaturase gene expression is sterol-regulatory element binding protein-1c (SREBP-1c) which mediates transcriptional activation of the SCD and D6D genes by insulin and inhibition by highly unsaturated fatty acids. % Highly unsaturated fatty acids decrease stability of SREBP-1 mRNA...SREBP-1c activates the transcription of SCD-1, D6D and probably D5D genes." provenance.
- _4 wasQuotedFrom 12440976 provenance.