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- _3 value "The activation of MAP-family kinase pathways leads to the activation of Mnk and hence eIF4E phosphorylation Mnk activation by oxidative stress leading to enhanced eIF4E phosphorylation may play a role in promoting stress-induced hyperproliferative diseases, such as smooth muscle cell proliferation and hypertrophy in cardiovascular disease, as the synthesis of several key regulators of cell growth has been shown to be held in check by moderation of eIF4E activity." provenance.
- _3 wasQuotedFrom 15683719 provenance.