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- _6 value "the factor VIIa-tissue factor (extrinsic) complex catalyzes the activation of both factor IX and factor X the initial product formed by the extrinsic factor Xase is factor Xa the factor IX zymogen is competitive with factor X and requires 2 peptide bond cleavages at arginine 145 and 180 for activity both of these cleavages are catalyzed by factor VIIa-tissue factor factor Xa, bound to a membrane, provides one of the 2 required cleavages (arginine 145) to produce intermediate factor IXalpha this feedback cleavage by membrane-bound factor Xa enhances the rate of generation of factor IXa, which is completed with the second bond cleavage (arginine 180) by factor VIIa-tissue factor" provenance.
- _6 wasQuotedFrom 12524220 provenance.