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- _4 value "However, other groups have not found an improvement in the differentiation capacity of brown pre-adipocytes upon inhibition of MAPK (Fasshauer et al. 2001). In addition to adipogenesis, insulin and IGF-I are novel thermogenic factors through the ability to increase UCP- 1 gene transcription rate and also UCP-1 mRNA accumulation (Lorenzo et al. 1993). Moreover, insulin and IGF-I transactivate the fusion gene containing the UCP-1 full promoter controlling the reporter gene chloramphenicol acetyl transferase (CAT), in a tissue-specific manner. Inhibition of PI3K with LY294002 completely blocked insulin/IGF-I-induced transactivation of the UCP-1 promoter and UCP-1 mRNA accumulation (Teruel et al. 1998)." provenance.
- _4 wasQuotedFrom 15777261 provenance.