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- _5 value "APC induces rapid phosphorylation of S1P1 on threonine residue 236 via an EPCR and PI3-kinase/AKT-dependent pathway and mediates Rac1-dependent cytoskeleton reorganization. Silencing of S1P1 expression using siRNA significantly reduces APC-mediated barrier protection against thrombin (Finigan et al., 2005)." provenance.
- _5 wasQuotedFrom 18973762 provenance.